lactotransferrin
Sign in to saveAlso known as neutrophil lactoferrin, LTF, lactoferroxin, epididymis luminal protein 110, talalactoferrin, growth-inhibiting protein 12, kaliocin-1, lactoferrin
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum ("first milk") has the highest concentration, followed by human milk, then cow milk (150 mg/L).
Protein · UniProt
Lactotransferrin
- Gene
- LTF
- Organism
- Homo sapiens (Human)
- Length
- 710 aa
- Molecular mass
- 78,182 Da
- Evidence
- 1: Evidence at protein level
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
121 registered- PHASE3COMPLETEDLactoferrin Infant Feeding Trial - LIFT_CanadaDr. Elizabeth Asztalos · NCT03367013
- PHASE4COMPLETEDLactoferrin Versus Iron Supplement in Irondeficiency Anemia and Weight Loss in Obese ChildrenAin Shams University · NCT04014855
- PHASE4UNKNOWNthe Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic TonsillitisSouth Valley University · NCT03748043
- PHASE4UNKNOWNComparative Study Between Oral Liposomal Iron,Iron Supported Lactoferrin and IV Iron Dextran in CKD ChildrenMenoufia University · NCT05714176
- PHASE1/PHASE2WITHDRAWNA Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Proven CandidaemiaAM-Pharma · NCT00509834
- NACOMPLETEDEffect of Infant Formula With Bovine Lactoferrin and Low Iron Concentration on Infant Health and Immune FunctionUmeå University · NCT02103205
Wikidata facts
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- Lactoferrin
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- purl.uniprot.org/uniprot/P02788
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~18 min read
Article
24 sectionsContents
- History
- Structure
- Genes of lactoferrin
- Molecular structure
- Polymeric forms
- Function
- Enzymatic activity of lactoferrin
- Lactoferrin receptor
- Bone activity
- Interaction with nucleic acids
- Clinical significance
- Antibacterial activity
- Antiviral activity
- Antifungal activity
- Anticarcinogenic activity
- Cystic fibrosis
- Necrotizing enterocolitis
- In diagnosis
- Technology
- Extraction
- Nanotechnology
- See also
- References
- External links
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum ("first milk") has the highest concentration, followed by human milk, then cow milk (150 mg/L).
Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucosas. It is constantly produced and released into saliva, tears, as well as seminal and vaginal fluid. Lactoferrin provides antibacterial activity to human infants. Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands.