FARP1

Also known as CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

Gene data

FARP1

Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Type: protein-coding
Position: 98,142,165–98,455,176 (+)
Aliases: CDEP, FARP1-IT1, GLCC1, PLEKHC2, PPP1R75
Ensembl: ENSG00000152767
RefSeq RNA: NM_001001715.4, NM_001286839.2, NM_005766.4
RefSeq protein: NP_001001715.2, NP_001273768.1, NP_005757.1

This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

Pathways

Signal Transduction Signaling by Rho GTPases RHOA GTPase cycle RHO GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle Signaling by Rho GTPases, Miro GTPases and RHOBTB3

via MyGene.info

Gene · Ensembl

FERM, ARH/RhoGEF and pleckstrin domain protein 1

Symbol: FARP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:98,142,165-98,455,176
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 38098
exact match: identifiers.org/ncbigene/10160
genomic end: 99102027
genomic start: 98794816
cytogenetic location: 13q32.2

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FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.