PLEKHA1

Also known as TAPP1, pleckstrin homology domain containing A1

Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to PLEKHA1, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Vinony links it to 6 Wikipedia language editions.

Gene data

PLEKHA1

Name: pleckstrin homology domain containing A1
Type: protein-coding
Position: 122,374,222–122,434,367 (+)
Aliases: TAPP1
Ensembl: ENSG00000107679
RefSeq RNA: NM_001001974.4, NM_001195608.2, NM_001330178.2, NM_001377230.1, NM_001377231.1
RefSeq protein: NP_001001974.1, NP_001182537.1, NP_001317107.1, NP_001364159.1, NP_001364160.1

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010].