PLEKHG5
Sign in to saveAlso known as CMTRIC, DSMA4, GEF720, Syx, Tech, pleckstrin homology and RhoGEF domain containing G5
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.
In the Vinony graph
Within Vinony's link graph, PLEKHG5 is referenced by 6 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 1 and Human proteins.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PLEKHG5- Name
- pleckstrin homology and RhoGEF domain containing G5
- Type
- protein-coding
- Position
- 6,467,122–6,520,074 (−)
- Aliases
- ARHGEF45, CMTRIC, DSMA4, GEF720, HMNR4, Syx, Tech
- Ensembl
- ENSG00000171680
- RefSeq RNA
- NM_001042663.3, NM_001042664.2, NM_001042665.2, NM_001265592.2, NM_001265593.2
- RefSeq protein
- NP_001036128.2, NP_001036129.1, NP_001036130.1, NP_001252521.2, NP_001252522.1
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
pleckstrin homology and RhoGEF domain containing G5
- Symbol
- PLEKHG5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:6,467,122-6,520,074
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 10768
- chromosome
- human chromosome 1
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57449
- genomic end
- 6520074
- genomic start
- 6467122
- cytogenetic location
- 1p36.31
- expressed in
- ganglionic eminence
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- Clinical significance
- References
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.
== Function ==
Excerpted from Wikipedia’s “PLEKHG5” article, available under the CC BY-SA 4.0 licence.