PHLDA2
Sign in to saveAlso known as BRW1C, BWR1C, HLDA2, IPL, TSSC3, pleckstrin homology like domain family A member 2
Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to PHLDA2, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Vinony links it to 5 Wikipedia language editions.
Gene data
PHLDA2- Name
- pleckstrin homology like domain family A member 2
- Type
- protein-coding
- Position
- 2,928,273–2,929,593 (−)
- Aliases
- BRW1C, BWR1C, HLDA2, IPL, TSSC3
- Ensembl
- ENSG00000274538
- RefSeq RNA
- NM_003311.4
- RefSeq protein
- NP_003302.1
This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
pleckstrin homology like domain family A member 2
- Symbol
- PHLDA2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:2,928,273-2,929,593
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2482
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7262
- chromosome
- human chromosome 11
- genomic start
- 2949503
- genomic end
- 2929420
- cytogenetic location
- 11p15.4
- expressed in
- testicle
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.
This gene is one of several genes in the imprinted gene domain of 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.
Excerpted from Wikipedia’s “PHLDA2” article, available under the CC BY-SA 4.0 licence.