PHLDA2

Also known as BRW1C, BWR1C, HLDA2, IPL, TSSC3, pleckstrin homology like domain family A member 2

Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.

Gene data

PHLDA2

Name: pleckstrin homology like domain family A member 2
Type: protein-coding
Aliases: BRW1C, BWR1C, HLDA2, IPL, TSSC3

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].

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Wikidata facts

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HomoloGene ID: 2482
exact match: identifiers.org/ncbigene/7262
genomic start: 2949503
genomic end: 2929420
cytogenetic location: 11p15.4

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Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2 gene.

This gene is one of several genes in the imprinted gene domain of 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.