FERMT2

Also known as KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2, fermitin family member 2, URP2SF

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene.

In the Vinony graph

Vinony's link graph records 7 inbound references to FERMT2, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Vinony links it to 5 Wikipedia language editions.

Gene data

FERMT2

Name: FERM domain containing kindlin 2
Type: protein-coding
Position: 52,856,943–52,952,435 (−)
Aliases: KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2
Ensembl: ENSG00000073712
RefSeq RNA: NM_001134999.2, NM_001135000.2, NM_006832.3, XM_005267285.4, XM_006720008.4
RefSeq protein: NP_001128471.1, NP_001128472.1, NP_006823.1, XP_005267342.1, XP_006720071.1

Enables several functions, including actin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol; focal adhesion; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

Cell-Cell communication Signal Transduction Signaling by Rho GTPases Cell-extracellular matrix interactions Cell junction organization RHO GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle Signaling by Rho GTPases, Miro GTPases and RHOBTB3

via MyGene.info

Gene · Ensembl

FERM domain containing kindlin 2

Symbol: FERMT2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:52,856,943-52,952,435
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 4976
cytogenetic location: 14q22.1
genetic association: Alzheimer's disease
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10979
genomic end: 53419153
genomic start: 53323986
chromosome: human chromosome 14

Sources (6)

via Wikidata · CC0

~2 min read

Encyclopedic overview

6 sections

Contents

Function
Interactions
Role in health and diseases
References
Further reading
External links

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene.

Kindlin-2 is the first of the kindlin protein to be discovered in 1994. It was detected in a screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein.

Excerpted from Wikipedia’s “FERMT2” article, available under the CC BY-SA 4.0 licence.