PLEK2
Sign in to saveAlso known as pleckstrin 2
Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.
Gene data
PLEK2- Name
- pleckstrin 2
- Type
- protein-coding
- Position
- 67,385,652–67,412,176 (−)
- Ensembl
- ENSG00000100558
- RefSeq RNA
- NM_016445.3, XM_047431262.1, XM_047431263.1, XM_054375851.1, XM_054375852.1
- RefSeq protein
- NP_057529.1, XP_047287218.1, XP_047287219.1, XP_054231826.1, XP_054231827.1
The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
pleckstrin 2
- Symbol
- PLEK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:67,385,652-67,412,236
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PLEK2 PDB 1v3f.png
Show 5 more facts
- HomoloGene ID
- 8447
- exact match
- identifiers.org/ncbigene/26499
- genomic end
- 67412167
- genomic start
- 67386984
- cytogenetic location
- 14q23.3-q24.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.
==References==