PLEK2

Also known as pleckstrin 2

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.

Gene data

PLEK2

Name: pleckstrin 2
Type: protein-coding
Position: 67,385,652–67,412,176 (−)
Ensembl: ENSG00000100558
RefSeq RNA: NM_016445.3, XM_047431262.1, XM_047431263.1, XM_054375851.1, XM_054375852.1
RefSeq protein: NP_057529.1, XP_047287218.1, XP_047287219.1, XP_054231826.1, XP_054231827.1

The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

actin cytoskeleton organization actin cytoskeleton organization intracellular signal transduction

Article

2 sections

Contents

References
Further reading

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene. The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.

==References==