FBLIM1
Sign in to saveAlso known as CAL, FBLP-1, FBLP1, filamin binding LIM protein 1
Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.
In the Vinony graph
Vinony's link graph records 5 inbound references to FBLIM1, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 7 Wikipedia language editions.
Gene data
FBLIM1- Name
- filamin binding LIM protein 1
- Type
- protein-coding
- Position
- 15,756,604–15,786,594 (+)
- Aliases
- CAL, FBLP-1, FBLP1
- Ensembl
- ENSG00000162458
- RefSeq RNA
- NM_001024215.1, NM_001024216.3, NM_001350151.2, NM_017556.4, XM_005245900.2
- RefSeq protein
- NP_001019386.1, NP_001019387.1, NP_001337080.1, NP_060026.2, XP_005245957.1
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
filamin binding LIM protein 1
- Symbol
- FBLIM1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:15,756,604-15,786,594
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FBLIM1 PDB 2K9U.png
Show 8 more facts
- HomoloGene ID
- 56774
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/54751
- genomic end
- 16113089
- genomic start
- 16083102
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.21
- expressed in
- left coronary artery
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “FBLIM1” article, available under the CC BY-SA 4.0 licence.