Also known as ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD
Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene.
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].
Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene.
== Structure == The structure of filamin A, alpha includes an actin binding N terminal domain, 24 internal repeats and 2 hinge regions.
Biological process
via MyGene.info
via Wikidata · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).