FMOD
Sign in to saveAlso known as FM, SLRR2E, fibromodulin
Fibromodulin is a protein that in humans is encoded by the FMOD gene.
Gene data
FMOD- Name
- fibromodulin
- Type
- protein-coding
- Aliases
- FM, SLRR2E
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
via MyGene.info
Gene · Ensembl
fibromodulin
- Symbol
- FMOD
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:203,340,441-203,351,758
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1530
- exact match
- identifiers.org/ncbigene/2331
- genomic end
- 203351758
- genomic start
- 203309756
- cytogenetic location
- 1q32.1
Sources (3)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Fibromodulin is a protein that in humans is encoded by the FMOD gene.
Fibromodulin is a 42kDa protein of a family of small interstitial leucine-rich repeat proteoglycans (SLRPs). It can have up to four N-linked keratan sulfate chains attached to the core protein within the leucine-rich region. It shares significant sequence homology with biglycan and decorin.