FGL1
Sign in to saveAlso known as HFREP1, HP-041, LFIRE-1, LFIRE1, fibrinogen like 1, HPS
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene. It is classified as a hepatokine. Four splice variants exist for this gene.
In the Vinony graph
Within Vinony's link graph, FGL1 is referenced by 4 other articles, and connects out to PubMed, T-lymphocytes and human chromosome 8.
It is catalogued under the topic Genes on human chromosome 8.
Its subject is documented across 6 Wikipedia language editions.
Gene data
FGL1- Name
- fibrinogen like 1
- Type
- protein-coding
- Position
- 17,841,833–17,910,383 (−)
- Aliases
- HFREP1, HP-041, HPS, LFIRE-1, LFIRE1
- Ensembl
- ENSG00000104760
- RefSeq RNA
- NM_004467.4, NM_147203.2, NM_201552.1, NM_201553.1, XM_047421577.1
- RefSeq protein
- NP_004458.3, NP_671736.2, NP_963846.1, NP_963847.1, XP_047277533.1
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
fibrinogen like 1
- Symbol
- FGL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:17,841,833-17,910,383
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 37927
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2267
- genomic end
- 17767874
- genomic start
- 17721889
- chromosome
- human chromosome 8
- cytogenetic location
- 8p22
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene. It is classified as a hepatokine. Four splice variants exist for this gene.
== Function ==
Excerpted from Wikipedia’s “FGL1” article, available under the CC BY-SA 4.0 licence.