FGFBP1

Also known as FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Gene data

FGFBP1

Name: fibroblast growth factor binding protein 1
Type: protein-coding
Position: 15,934,507–15,939,171 (−)
Aliases: FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17
Ensembl: ENSG00000137440
RefSeq RNA: NM_005130.5
RefSeq protein: NP_005121.1

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011].

Gene Ontology

Biological process

signal transduction

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Article

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Further reading

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).[supplied by OMIM]