FBXO32

Also known as Fbx32, MAFbx, F-box protein 32

F-box only protein 32, also known as "MAFbx", for "Muscle Atrophy F-box gene", and "Atrogin-1," is a protein that in humans is encoded by the FBXO32 gene.

Gene data

FBXO32

Name: F-box protein 32
Type: protein-coding
Position: 123,497,889–123,541,273 (−)
Aliases: Fbx32, MAFbx
Ensembl: ENSG00000156804
RefSeq RNA: NM_001242463.2, NM_058229.4, NM_148177.3
RefSeq protein: NP_001229392.1, NP_478136.1, NP_680482.1

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].

Gene Ontology

Biological process

response to denervation involved in regulation of muscle adaptation response to denervation involved in regulation of muscle adaptation protein ubiquitination protein ubiquitination protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

Molecular function

protein binding ubiquitin-like ligase-substrate adaptor activity

Cellular component

nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytoplasm cytoplasm

Pathways

FoxO signaling pathway - Homo sapiens (human)Adaptive Immune System Immune System Generic Transcription Pathway Metabolism of proteins Post-translational protein modification RNA Polymerase II Transcription Gene expression (Transcription)Neddylation FOXO-mediated transcription

via MyGene.info

Gene · Ensembl

F-box protein 32

Symbol: FBXO32
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:123,497,889-123,541,273
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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Encyclopedic overview

5 sections

Contents

Function
Interactions
Cancer
References
Further reading

F-box only protein 32, also known as "MAFbx", for "Muscle Atrophy F-box gene", and "Atrogin-1," is a protein that in humans is encoded by the FBXO32 gene.

== Function ==

Excerpted from Wikipedia’s “FBXO32” article, available under the CC BY-SA 4.0 licence.

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