File:PDB_1m1j_EBI.jpg · Wikimedia Commons · See Wikimedia Commons
fibrinogen complex
Sign in to saveAlso known as fibrinogen complex family, fibrinogen, GO:0005577, factor I
Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiog
Key facts
- Protein.OMIM
- 134830
- Protein family.Symbol
- Fibrinogen_C
- Protein family.Name
- Fibrinogen alpha/beta chain family
- Protein family.image
- PDB 1m1j EBI.jpg
- Protein family.caption
- crystal structure of native chicken fibrinogen with two different bound ligands
- Protein family.Pfam
- PF00147
- Protein family.InterPro
- IPR002181
- Protein family.SCOP
- 1fza
- Protein family.Pfam_clan
- CL0422
- Protein family.PROSITE
- PDOC00445
- Protein.Name
- Fibrinogen beta chain
- Protein.HGNCid
- 3662
- Protein.Symbol
- FGB
- Protein.EntrezGene
- 2244
- Protein.RefSeq
- NM_000508
- Protein.UniProt
- P02671
- Protein.Chromosome
- 4
- Protein.Arm
- q
via Wikipedia infobox
Research
8,728 papers- Synergistic effects of the Aβ/fibrinogen complex on synaptotoxicity, neuroinflammation, and blood-brain barrier damage in Alzheimer's disease models.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
- Lecanemab blocks the effects of the Aβ/fibrinogen complex on blood clots and synapse toxicity in organotypic culture.Proceedings of the National Academy of Sciences of the United States of America · 2024
- Fibrinogen and fibrin.Advances in protein chemistry · 2005
- Mechanism of fibrinogen /microparticle complex deposition on solid substrates: Role of pH.Colloids and surfaces. B, Biointerfaces · 2019
- Complement amplification revisited.Molecular immunology · 2006
via PubMed
Wikidata facts
- Image
- Fibrinandligand.png
Show 2 more facts
- exact match
- purl.obolibrary.org/obo/GO_0005577
- Commons category
- Fibrinogen
via Wikidata · CC0
~16 min read
Article
18 sectionsContents
- Genes
- Structure
- Blood clot formation
- Fibrinogen disorders
- Congenital afibrinogenemia
- Congenital hypofibrinogenemia
- Fibrinogen storage disease
- Congenital dysfibrinogenemia
- Hereditary fibrinogen Aα-Chain amyloidosis
- Acquired dysfibrinogenemia
- Congenital hypodysfibrinogenemia
- Cryofibrinogenemia
- Acquired hypofibrinogenemia
- Laboratory tests
- Hyperfibrinogenemia
- History
- References
- External links
Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.
Reduced and/or dysfunctional fibrinogens occur in various congenital and acquired human fibrinogen-related disorders. These disorders represent a group of rare conditions in which individuals may present with severe episodes of pathological bleeding and thrombosis; these conditions are treated by supplementing blood fibrinogen levels and inhibiting blood clotting, respectively. These disorders may also be the cause of certain liver and kidney diseases.