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GeneQ17927049· pop 5· linked from 46 articles

FABP1

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Also known as FABPL, L-FABP, fatty acid binding protein 1

FABP1 is a human gene coding for the protein product FABP1 (Fatty Acid-Binding Protein 1). It is also frequently known as liver-type fatty acid-binding protein (LFABP).

Gene data

FABP1
Name
fatty acid binding protein 1
Type
protein-coding
Position
88,122,982–88,128,122 (−)
Aliases
FABPL, L-FABP
Ensembl
ENSG00000163586
RefSeq RNA
NM_001443.3, XM_054341028.1
RefSeq protein
NP_001434.1, XP_054197003.1

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011].

Gene Ontology

Pathways

PPAR signaling pathway - Homo sapiens (human)Fat digestion and absorption - Homo sapiens (human)MetabolismTriglyceride catabolismMetabolism of porphyrinsHeme degradationPPARA activates gene expressionCellular responses to stressRegulation of lipid metabolism by PPARalphaMetabolism of lipids

via MyGene.info

Gene · Ensembl

fatty acid binding protein 1

Symbol
FABP1
Biotype
Protein coding
Organism
Homo sapiens
Location
2:88,122,982-88,128,122
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

11 sections
Contents
  • Discovery
  • Gene location
  • Protein structure
  • Function
  • Mutations
  • Protein expression
  • Suppression
  • Increased levels in obesity
  • Disease marker
  • References
  • Further reading

FABP1 is a human gene coding for the protein product FABP1 (Fatty Acid-Binding Protein 1). It is also frequently known as liver-type fatty acid-binding protein (LFABP).

FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids (and less so for synthetic cannabinoid receptor (CBR) agonists and antagonists) and other hydrophobic molecules. Altered expression of the protein has been linked to metabolic conditions including obesity.

Excerpted from Wikipedia’s “FABP1” article, available under the CC BY-SA 4.0 licence.

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