IGFBP1

Also known as AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

Gene data

IGFBP1

Name: insulin like growth factor binding protein 1
Type: protein-coding
Position: 45,888,360–45,893,660 (+)
Aliases: AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1
Ensembl: ENSG00000146678
RefSeq RNA: NM_000596.4, NM_001013029.1, XM_054358118.1
RefSeq protein: NP_000587.1, XP_054214093.1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017].

Gene Ontology

Biological process

signal transduction

Article

3 sections

Contents

Function
References
Further reading

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

== Function ==