IGFBP1

Also known as AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

Gene data

IGFBP1

Name: insulin like growth factor binding protein 1
Type: protein-coding
Position: 45,888,360–45,893,660 (+)
Aliases: AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1
Ensembl: ENSG00000146678
RefSeq RNA: NM_000596.4, NM_001013029.1, XM_054358118.1
RefSeq protein: NP_000587.1, XP_054214093.1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017].

Gene Ontology

Biological process

signal transduction insulin receptor signaling pathway positive regulation of cell growth tissue regeneration regulation of insulin-like growth factor receptor signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway

Molecular function

signaling receptor binding protein binding insulin-like growth factor binding insulin-like growth factor binding insulin-like growth factor I binding insulin-like growth factor I binding insulin-like growth factor II binding insulin-like growth factor II binding

Cellular component

extracellular region extracellular region extracellular region endoplasmic reticulum lumen

Pathways

Generic Transcription Pathway Cellular responses to stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression Unfolded Protein Response (UPR)Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Metabolism of proteins Post-translational protein modification RNA Polymerase II Transcription Gene expression (Transcription)

via MyGene.info

Gene · Ensembl

insulin like growth factor binding protein 1

Symbol: IGFBP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:45,888,360-45,893,660
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IGFBP1 PDB 1zt3.png

Show 6 more facts

HomoloGene ID: 498
exact match: identifiers.org/ncbigene/3484
genomic end: 45893660
genomic start: 45888360
cytogenetic location: 7p12.3
Commons category: IGFBP1

Sources (4)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

Function
References
Further reading

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

== Function ==