intercellular adhesion molecule 3
Sign in to saveAlso known as ICAM3, CDw50, ICAM-3, ICAM-R, Intercellular Adhesion Molecule-3
Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene. The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through its facilitation of interactions between T cells and dendritic cells, which allows for T cell activation. ICAM3 also mediates the clearance of cells undergoing
Protein · UniProt
Intercellular adhesion molecule 3
- Gene
- ICAM3
- Organism
- Homo sapiens (Human)
- Length
- 547 aa
- Molecular mass
- 59,541 Da
- Evidence
- 1: Evidence at protein level
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring apoptotic neutrophil phagocytosis by macrophages (PubMed:1448173, PubMed:1448174, PubMed:23775590, PubMed:8325327, PubMed:8459213). Is also a ligand for integrin ITGAD/ITGB2 (PubMed:8777714). Ligand of CD209 on dendritic cells (DC) through an integrin-independent mechanism that requires Ca(2+) and that forms a first contact between DC and resting T cell, facilitating the downstream DC-T cell clustering process and DC-induced prolif…
Swiss-Prot (reviewed) · via UniProt
~4 min read
Encyclopedic overview
14 sectionsContents
- Protein structure
- Function
- Dendritic and T cell binding
- Apoptosis
- Mast cells
- Interactions
- Dendritic and T cell binding
- Apoptosis
- Integrins
- Additional interactions
- See also
- References
- Further reading
- External links
Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene. The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through its facilitation of interactions between T cells and dendritic cells, which allows for T cell activation. ICAM3 also mediates the clearance of cells undergoing apoptosis by attracting and binding macrophages, a type of cell that breaks down infected or dying cells through a process known as phagocytosis, to apoptotic cells.
== Protein structure == ICAM3 is a 110–160 kDa protein that belongs to the intercellular adhesion molecule (ICAM) family. Like the other proteins in this family, ICAM3 is a type I transmembrane glycoprotein and consists in part of a hydrophobic transmembrane domain and a short domain that extends into the cytoplasm. ICAM3 also contains five extracellular immunoglobulin domains.
Excerpted from Wikipedia’s “intercellular adhesion molecule 3” article, available under the CC BY-SA 4.0 licence.