CDC6

Also known as CDC18L, HsCDC18, HsCDC6, cell division cycle 6, MGORS5

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

Gene data

CDC6

Name: cell division cycle 6
Type: protein-coding
Aliases: CDC18L, HsCDC18, HsCDC6, MGORS5

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cell division cycle 6

Symbol: CDC6
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:40,287,831-40,304,657
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: PDB 2cch EBI.jpg

Show 5 more facts

HomoloGene ID: 68172
genomic start: 40287879
exact match: identifiers.org/ncbigene/990
genomic end: 38459171
cytogenetic location: 17q21.2

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Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.