MCM7

Also known as CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104, minichromosome maintenance complex component 7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

Gene data

MCM7

Name: minichromosome maintenance complex component 7
Type: protein-coding
Position: 100,092,233–100,101,940 (−)
Aliases: CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Ensembl: ENSG00000166508
RefSeq RNA: NM_001278595.2, NM_001439271.1, NM_001439272.1, NM_001439273.1, NM_005916.5
RefSeq protein: NP_001265524.1, NP_001426200.1, NP_001426201.1, NP_001426202.1, NP_005907.3

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].