MCM8
Sign in to saveAlso known as C20orf154, dJ967N21.5, POF10, minichromosome maintenance 8 homologous recombination repair factor
DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.
Gene data
MCM8- Name
- minichromosome maintenance 8 homologous recombination repair factor
- Type
- protein-coding
- Aliases
- C20orf154, POF10, dJ967N21.5
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013].
via MyGene.info
Gene · Ensembl
minichromosome maintenance 8 homologous recombination repair factor
- Symbol
- MCM8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:5,949,767-5,998,977
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 12001
- genomic end
- 5998977
- exact match
- identifiers.org/ncbigene/84515
- genomic start
- 5931298
- cytogenetic location
- 20p12.3
via Wikidata · CC0
~3 min read
Article
4 sectionsContents
- DNA repair
- See also
- References
- Further reading
DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.