MCM4

Also known as CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21, minichromosome maintenance complex component 4, IMD54

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

In the Vinony graph

Within Vinony's link graph, MCM4 is referenced by 95 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Human genes.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MCM4

Name: minichromosome maintenance complex component 4
Type: protein-coding
Position: 47,960,185–47,979,181 (+)
Aliases: CDC21, CDC54, IMD54, NKCD, NKGCD, P1-CDC21, hCdc21
Ensembl: ENSG00000104738
RefSeq RNA: NM_005914.4, NM_182746.3
RefSeq protein: NP_005905.2, NP_877423.1

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].