MCM5

Also known as CDC46, P1-CDC46, minichromosome maintenance complex component 5, MGORS8

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.

Gene data

MCM5

Name: minichromosome maintenance complex component 5
Type: protein-coding
Position: 35,400,123–35,425,431 (+)
Aliases: CDC46, MGORS8, P1-CDC46
Ensembl: ENSG00000100297
RefSeq RNA: NM_006739.4, XM_006724242.5, XM_047441366.1, XM_054325620.1, XM_054325621.1
RefSeq protein: NP_006730.2, XP_006724305.1, XP_047297322.1, XP_054181595.1, XP_054181596.1

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008].