FEN1

Name

flap structure-specific endonuclease 1

Type

protein-coding

Position

61,792,725–61,797,238 (+)

Aliases

FEN-1, MF1, RAD2

Ensembl

ENSG00000168496

RefSeq RNA

NM_004111.6

RefSeq protein

NP_004102.1

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

flap structure-specific endonuclease 1

Symbol

FEN1

Biotype

Protein coding

Organism

Homo sapiens

Location

11:61,792,725-61,797,238

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein FEN1 PDB 1ul1.png

via Wikidata · CC0