Also known as C1orf16, EST1C, SGA56M, SMG7, nonsense mediated mRNA decay factor, SMG7 nonsense mediated mRNA decay factor
Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011].
via MyGene.info
~1 min read
Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.
== References ==
via Wikidata · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).