ACTL7A
Sign in to saveAlso known as actin like 7A
Actin-like protein 7A is a protein that in humans is encoded by the ACTL7A gene.
Gene data
ACTL7A- Name
- actin like 7A
- Type
- protein-coding
- Aliases
- SPGF86
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
actin like 7A
- Symbol
- ACTL7A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:108,862,266-108,863,756
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 7613
- exact match
- identifiers.org/ncbigene/10881
- genomic end
- 108863756
- genomic start
- 111624603
- cytogenetic location
- 9q31.3
Sources (4)
via Wikidata · CC0
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Actin-like protein 7A is a protein that in humans is encoded by the ACTL7A gene.
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.