ACTN1

Name

actinin alpha 1

Type

protein-coding

Position

68,874,121–68,980,277 (−)

Aliases

BDPLT15

Ensembl

ENSG00000072110

RefSeq RNA

NM_001102.4, NM_001130004.2, NM_001130005.2, NM_001411035.1, NM_001411036.1

RefSeq protein

NP_001093.1, NP_001123476.1, NP_001123477.1, NP_001397964.1, NP_001397965.1

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

actinin alpha 1

Symbol

ACTN1

Biotype

Protein coding

Organism

Homo sapiens

Location

14:68,873,643-68,980,277

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein ACTN1 PDB 1sjj.png

via Wikidata · CC0