ACTR2
Sign in to saveAlso known as ARP2, ARP2 actin-related protein 2 homolog (yeast), ARP2 actin related protein 2 homolog, actin related protein 2, Actin related protein 2/3 complex subunit 2, p34-ARC, ARPC2, arp2/3 complex 34 kDa subunit
Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.
In the Vinony graph
Vinony's link graph records 4 inbound references to ACTR2, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 6 Wikipedia language editions.
Gene data
ACTR2- Name
- actin related protein 2
- Type
- protein-coding
- Position
- 65,227,714–65,271,253 (+)
- Aliases
- ARP2
- Ensembl
- ENSG00000138071
- RefSeq RNA
- NM_001005386.3, NM_005722.4
- RefSeq protein
- NP_001005386.1, NP_005713.1
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
actin related protein 2
- Symbol
- ACTR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:65,227,714-65,271,253
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Protein · UniProt
Actin-related protein 2/3 complex subunit 2
- Gene
- ARPC2
- Organism
- Homo sapiens (Human)
- Length
- 300 aa
- Molecular mass
- 34,333 Da
- Evidence
- 1: Evidence at protein level
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Ar…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
- Image
- Protein ACTR2 PDB 1k8k.png
Show 8 more facts
- HomoloGene ID
- 4181
- genomic start
- 65227788
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10097
- genomic end
- 65498387
- chromosome
- human chromosome 2
- cytogenetic location
- 2p14
- Commons category
- ARPC2
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- References
- External links
- Further reading
- External links
Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.
== Function ==
Excerpted from Wikipedia’s “ACTR2” article, available under the CC BY-SA 4.0 licence.