SMC5

Also known as SMC5L1, structural maintenance of chromosomes 5

Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.

Gene data

SMC5

Name: structural maintenance of chromosomes 5
Type: protein-coding
Position: 70,258,270–70,354,874 (+)
Aliases: ATELS2, SMC5L1
Ensembl: ENSG00000198887
RefSeq RNA: NM_015110.4, XM_005251837.3, XM_005251838.3, XM_005251839.3, XM_017014507.2
RefSeq protein: NP_055925.2, XP_005251894.1, XP_005251895.1, XP_005251896.1, XP_016869996.1

Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

telomere maintenance via recombination double-strand break repair via homologous recombination

Article

6 sections

Contents

Structure
Nse subunits
Localization in different organisms
Role in recombination and meiosis
References
Further reading

Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.

The structural maintenance of chromosomes' complex underlying mechanisms involved in the dynamics of chromatin dynamics is unknown, and discoveries are shedding light on the various functions. The SMC complex mediates long-distance interactions that enable higher-order chromatin folding in interphase. The SMC complex has an ATPase activity, a conserved kleisin, and regulatory subunits. SMC protein complexes are involved in DNA repair, transcriptional pathways, regulation of chromosome segregation, and immunity in Arabidopsis. In eukaryotes the structural maintenance chromosomes consists of cohesin (SMC1 AND SMC3), condensin (SMC2 and SMC4), and SMC5/6 complexes.