SMC4
Sign in to saveAlso known as CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C, structural maintenance of chromosomes 4
Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. SMC-4 is a core subunit of condensin I and II, large protein complexes involved in high order chromosome organization, including condensation and segregation. SMC-4 protein is commonly associated with the SMC-2 protein, another protein complex within the SMC protein family. SMC-4 dimerizes with SMC-2, creating the flexible and dynamic structure of the condensin holocomplex. An over-expression of the SMC-4 pr
Gene data
SMC4- Name
- structural maintenance of chromosomes 4
- Type
- protein-coding
- Aliases
- CAP-C, CAPC, SMC-4, SMC4L1
This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016].
via MyGene.info
Gene · Ensembl
structural maintenance of chromosomes 4
- Symbol
- SMC4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:160,399,274-160,437,759
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4015
- exact match
- identifiers.org/ncbigene/10051
- genomic end
- 160434954
- genomic start
- 160117062
- cytogenetic location
- 3q25.33
Sources (4)
via Wikidata · CC0
~4 min read
Article
5 sectionsContents
- Structure and interactions
- Clinical significance
- References
- Further reading
- External links
Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene. SMC-4 is a core subunit of condensin I and II, large protein complexes involved in high order chromosome organization, including condensation and segregation. SMC-4 protein is commonly associated with the SMC-2 protein, another protein complex within the SMC protein family. SMC-4 dimerizes with SMC-2, creating the flexible and dynamic structure of the condensin holocomplex. An over-expression of the SMC-4 protein is shown to impact carcinogenesis.
== Structure and interactions == thumb|Structure of a condensin protein holocomplex, displaying the SMC-4/SMC-2 heterodimer, and additional subunits. Kleisin is also depicted (blue).