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nucleolus

Also known as GO:0005730, cell nucleolus

thumb |292px |Nucleolus contained within the cell nucleus

AI overview

The nucleolus is a structure found inside the cell nucleus that plays a key role in making ribosomes, which are the cellular machines responsible for building proteins in living cells. This makes the nucleolus important for basic cell function, since producing proteins is essential for nearly all life processes.

AI-generated from the Wikipedia summary — may contain errors.

Research

18,968 papers

The nucleolus as a multiphase liquid condensate.ReviewNature reviews. Molecular cell biology · 2021Lafontaine DLJ, Riback JA, Bascetin R et al.DOI: 10.1038/s41580-020-0272-6
The Nucleolus and Its Associated Pathologies.ReviewWIREs mechanisms of disease · 2025Menjivar-Vallecillo MJ, Padilla-Claros NV, Gavarrete-Garrido P et al.DOI: 10.1002/wsbm.70003
The nucleolus of Giardia and its ribosomal biogenesis.ReviewParasitology research · 2023Lagunas-Rangel FADOI: 10.1007/s00436-023-07915-2
The nucleolus.ReviewCold Spring Harbor perspectives in biology · 2011Pederson TDOI: 10.1101/cshperspect.a000638
Nucleolus: A Central Hub for Nuclear Functions.ReviewTrends in cell biology · 2019Iarovaia OV, Minina EP, Sheval EV et al.DOI: 10.1016/j.tcb.2019.04.003
The nucleolus.ReviewAnatomy and embryology · 1993Schwarzacher HG, Wachtler FDOI: 10.1007/BF00187008
Therapeutic Approaches Targeting Nucleolus in Cancer.ReviewCells · 2019Carotenuto P, Pecoraro A, Palma G et al.DOI: 10.3390/cells8091090
Mechanobiology of the Nucleolus.ReviewBiology of the cell · 2026Shetty Y, Dolega MEDOI: 10.1111/boc.70052

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Wikidata facts

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Commons category: Cell nucleolus
exact match: purl.obolibrary.org/obo/GO_0005730

Sources (5)

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~7 min read

Article

8 sections

Contents

History
Structure
Function and ribosome assembly
Sequestration of proteins
See also
References
Further reading
External links

thumb |292px |Nucleolus contained within the cell nucleus

The nucleolus (; : nucleoli ) is the largest structure in the nucleus of eukaryotic cells. It is best known as the site of ribosome biogenesis. The nucleolus also participates in the formation of signal recognition particles and plays a role in the cell's response to stress. Nucleoli are made of proteins, DNA and RNA, and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of the nucleolus is the cause of several human conditions called "nucleolopathies" and the nucleolus is being investigated as a target for cancer chemotherapy.