SMC6
Sign in to saveAlso known as SMC-6, SMC6L1, hSMC6, structural maintenance of chromosomes 6
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.
In the Vinony graph
Within Vinony's link graph, SMC6 is referenced by 53 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 2.
Its subject is documented across 6 Wikipedia language editions.
Gene data
SMC6- Name
- structural maintenance of chromosomes 6
- Type
- protein-coding
- Position
- 17,662,940–17,800,242 (−)
- Aliases
- SMC-6, SMC6L1, hSMC6
- Ensembl
- ENSG00000163029
- RefSeq RNA
- NM_001142286.2, NM_024624.6, XM_011533107.4, XM_011533108.4, XM_017004913.3
- RefSeq protein
- NP_001135758.1, NP_078900.1, XP_011531409.1, XP_011531410.1, XP_016860402.1
Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
structural maintenance of chromosomes 6
- Symbol
- SMC6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:17,662,940-17,800,242
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 41575
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79677
- genomic end
- 17981509
- genomic start
- 17845079
- chromosome
- human chromosome 2
- cytogenetic location
- 2p24.2
Sources (4)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Nse subunits
- Localization
- Role in recombination and meiosis
- References
- Further reading
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.
== Structure == The SMC6 was discovered first in fission yeast as RAD18 (SMC6). It forms a heterodimeric complex with Spr18 (SMC5) protein. In yeast, SMC5/6 complex has sub-units which consists of SMC5, SMC6 and six nonstructural maintenance of chromosomes (NSE) proteins. Nse1-Nse3-Nse4 subunits bridge the Smc5 head Smc6 and allow the binding of DNA.
Excerpted from Wikipedia’s “SMC6” article, available under the CC BY-SA 4.0 licence.