SMC6

Also known as SMC-6, SMC6L1, hSMC6, structural maintenance of chromosomes 6

Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.

Gene data

SMC6

Name: structural maintenance of chromosomes 6
Type: protein-coding
Position: 17,663,583–17,800,242 (−)
Aliases: SMC-6, SMC6L1, hSMC6
Ensembl: ENSG00000163029
RefSeq RNA: NM_001142286.2, NM_024624.6, XM_011533107.4, XM_011533108.4, XM_017004913.3
RefSeq protein: NP_001135758.1, NP_078900.1, XP_011531409.1, XP_011531410.1, XP_016860402.1

Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

telomere maintenance via recombination double-strand break repair via homologous recombination

~3 min read

Article

6 sections

Contents

Structure
Nse subunits
Localization
Role in recombination and meiosis
References
Further reading

Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.

== Structure == The SMC6 was discovered first in fission yeast as RAD18 (SMC6). It forms a heterodimeric complex with Spr18 (SMC5) protein. In yeast, SMC5/6 complex has sub-units which consists of SMC5, SMC6 and six nonstructural maintenance of chromosomes (NSE) proteins. Nse1-Nse3-Nse4 subunits bridge the Smc5 head Smc6 and allow the binding of DNA.