ORC6

Also known as ORC6L, origin recognition complex subunit 6

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

In the Vinony graph

Vinony's link graph records 95 inbound references to ORC6, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

Vinony files it under Genes on human chromosome 16 and Protein pages needing a picture.

Vinony links it to 8 Wikipedia language editions.

Gene data

ORC6

Name: origin recognition complex subunit 6
Type: protein-coding
Position: 46,689,301–46,698,399 (+)
Aliases: ORC6L
Ensembl: ENSG00000091651
RefSeq RNA: NM_014321.4, NR_037620.2, XM_011522978.4, XM_054379984.1
RefSeq protein: NP_055136.1, XP_011521280.1, XP_054235959.1

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010].

Gene Ontology

Biological process

DNA replication DNA-templated DNA replication DNA replication initiation DNA replication initiation

Molecular function

DNA binding protein binding

Cellular component

origin recognition complex fibrillar center nucleus nucleus nucleoplasm nucleoplasm nuclear origin of replication recognition complex nuclear origin of replication recognition complex

Pathways

Cell cycle - Homo sapiens (human)E2F-enabled inhibition of pre-replication complex formation E2F mediated regulation of DNA replication Cell Cycle Cell Cycle Activation of ATR in response to replication stress Mitotic G1 phase and G1/S transition Mitotic G1 phase and G1/S transition Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex

via MyGene.info

Gene · Ensembl

origin recognition complex subunit 6

Symbol: ORC6
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:46,689,301-46,698,399
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 8635
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23594
genomic end: 46732306
genomic start: 46723555
chromosome: human chromosome 16
cytogenetic location: 16q11.2
expressed in: testicle

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

6 sections

Contents

Background
Function
Interactions
References
Further reading
External links

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

==Background== The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.

Excerpted from Wikipedia’s “ORC6” article, available under the CC BY-SA 4.0 licence.