ORC6

Also known as ORC6L, origin recognition complex subunit 6

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

Gene data

ORC6

Name: origin recognition complex subunit 6
Type: protein-coding
Aliases: ORC6L

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010].

via MyGene.info

Gene · Ensembl

origin recognition complex subunit 6

Symbol: ORC6
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:46,689,301-46,698,399
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8635
exact match: identifiers.org/ncbigene/23594
genomic end: 46732306
genomic start: 46723555
cytogenetic location: 16q11.2

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via Wikidata · CC0

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6 sections

Contents

Background
Function
Interactions
References
Further reading
External links

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

==Background== The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.