INTS6

Also known as DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.

Gene data

INTS6

Name: integrator complex subunit 6
Type: protein-coding
Position: 51,354,077–51,454,264 (−)
Aliases: DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2
Ensembl: ENSG00000102786
RefSeq RNA: NM_001039937.2, NM_001039938.2, NM_001306091.2, NM_012141.3, XM_011535040.4
RefSeq protein: NP_001035026.1, NP_001035027.1, NP_001293020.1, NP_036273.1, XP_011533342.1

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015].

Gene Ontology

Biological process

snRNA processing

Article

2 sections

Contents

References
Further reading

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.