INTS11

Also known as CPSF73L, INT11, RC-68, RC68, CPSF3L, cleavage and polyadenylation specific factor 3-like, integrator complex subunit 11

Integrator complex subunit 11 is a protein that in humans is encoded by the CPSF3L gene.

Gene data

INTS11

Name: integrator complex subunit 11
Type: protein-coding
Position: 1,311,585–1,324,687 (−)
Aliases: CPSF3L, CPSF73L, INT11, NEDMLOB, PSF3L, RC-68, RC68
Ensembl: ENSG00000127054
RefSeq RNA: NM_001256456.2, NM_001256460.2, NM_001256462.2, NM_001256463.2, NM_017871.6
RefSeq protein: NP_001243385.1, NP_001243389.1, NP_001243391.1, NP_001243392.1, NP_060341.2

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].