COPS6
Sign in to saveAlso known as CSN6, MOV34-34KD, COP9 signalosome subunit 6
COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.
Gene data
COPS6- Name
- COP9 signalosome subunit 6
- Type
- protein-coding
- Position
- 100,088,948–100,093,340 (+)
- Aliases
- CSN6, MOV34-34KD
- Ensembl
- ENSG00000168090
- RefSeq RNA
- NM_006833.5
- RefSeq protein
- NP_006824.2
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
COP9 signalosome subunit 6
- Symbol
- COPS6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:100,088,948-100,095,185
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4977
- exact match
- identifiers.org/ncbigene/10980
- genomic end
- 100092187
- genomic start
- 100088969
- cytogenetic location
- 7q22.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.
== Function ==