COPS4
Sign in to saveAlso known as CSN4, COP9 signalosome subunit 4, SGN4
COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to COPS4, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 4.
Vinony links it to 7 Wikipedia language editions.
Gene data
COPS4- Name
- COP9 signalosome subunit 4
- Type
- protein-coding
- Position
- 83,034,447–83,075,818 (+)
- Aliases
- CSN4, SGN4
- Ensembl
- ENSG00000138663
- RefSeq RNA
- NM_001258006.2, NM_001330727.2, NM_016129.3
- RefSeq protein
- NP_001244935.1, NP_001317656.1, NP_057213.2
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
COP9 signalosome subunit 4
- Symbol
- COPS4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:83,034,447-83,075,818
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein COPS4 PDB 1ufm.png
Show 7 more facts
- HomoloGene ID
- 8067
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51138
- genomic end
- 83996971
- genomic start
- 83955600
- chromosome
- human chromosome 4
- cytogenetic location
- 4q21.22
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
Excerpted from Wikipedia’s “COPS4” article, available under the CC BY-SA 4.0 licence.