STEAP4

Also known as STAMP2, TIARP, TNFAIP9, STEAP4 metalloreductase, SchLAH

STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.

Gene data

STEAP4

Name: STEAP4 metalloreductase
Type: protein-coding
Position: 88,270,892–88,307,010 (−)
Aliases: STAMP2, SchLAH, TIARP, TNFAIP9
Ensembl: ENSG00000127954
RefSeq RNA: NM_001205315.2, NM_001205316.2, NM_024636.4
RefSeq protein: NP_001192244.1, NP_001192245.1, NP_078912.2

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].