CKAP4

Also known as CLIMP-63, ERGIC-63, p63, cytoskeleton-associated protein 4, cytoskeleton associated protein 4, CLIMP63

Cytoskeleton-associated protein 4 is a protein that in humans is encoded by the CKAP4 gene.

In the Vinony graph

Within Vinony's link graph, CKAP4 is referenced by 2 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 12.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CKAP4

Name: cytoskeleton associated protein 4
Type: protein-coding
Position: 106,236,448–106,304,279 (−)
Aliases: CLIMP-63, CLIMP63, ERGIC-63, p63
Ensembl: ENSG00000136026
RefSeq RNA: NM_006825.4
RefSeq protein: NP_006816.2

Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular function

RNA binding protein binding

Cellular component

endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum membrane rough endoplasmic reticulum rough endoplasmic reticulum lipid droplet

Pathways

Protein processing in endoplasmic reticulum - Homo sapiens (human)Signal Transduction Innate Immune System Immune System Signaling by Rho GTPases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Metabolism of proteins Surfactant metabolism Post-translational protein modification Neutrophil degranulation

via MyGene.info

Gene · Ensembl

cytoskeleton associated protein 4

Symbol: CKAP4
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:106,236,448-106,304,279
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 4970
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10970
chromosome: human chromosome 12
genomic start: 106237881
genomic end: 106698057
cytogenetic location: 12q23.3

Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections

Contents

Discovery
Localization, molecular functions and regulation
Diseases
References
Further reading
External links

Cytoskeleton-associated protein 4 is a protein that in humans is encoded by the CKAP4 gene.

CKAP4 also historically known as CLIMP-63 (cytoskeleton-linking membrane protein 63), or just p63 (during the 1990s) is an abundant type II transmembrane protein residing predominantly in the endoplasmic reticulum (ER) of eukaryotic cells and encoded in higher vertebrates by the gene CKAP4.

Excerpted from Wikipedia’s “CKAP4” article, available under the CC BY-SA 4.0 licence.