EML4
Sign in to saveAlso known as C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4
Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.
In the Vinony graph
Vinony's link graph records 222 inbound references to EML4, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
EML4- Name
- EMAP like 4
- Type
- protein-coding
- Position
- 42,169,312–42,332,548 (+)
- Aliases
- C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120
- Ensembl
- ENSG00000143924
- RefSeq RNA
- NM_001145076.3, NM_001410776.1, NM_019063.5, XM_005264268.4, XM_006711991.2
- RefSeq protein
- NP_001138548.2, NP_001397705.1, NP_061936.3, XP_005264325.1, XP_006712054.1
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
EMAP like 4
- Symbol
- EML4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:42,169,312-42,332,548
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 56841
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27436
- genomic end
- 42559688
- genomic start
- 42169353
- chromosome
- human chromosome 2
- cytogenetic location
- 2p21
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.
This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.
Excerpted from Wikipedia’s “EML4” article, available under the CC BY-SA 4.0 licence.