CKAP5

Also known as CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton associated protein 5

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.

Gene data

CKAP5

Name: cytoskeleton associated protein 5
Type: protein-coding
Position: 46,743,048–46,846,308 (−)
Aliases: CHTOG, MSPS, TOG, TOGp, ch-TOG
Ensembl: ENSG00000175216
RefSeq RNA: NM_001008938.4, NM_014756.4
RefSeq protein: NP_001008938.1, NP_055571.2

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

Pathways

Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle Organelle biogenesis and maintenance Signaling by Rho GTPases RHO GTPase Effectors Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase

via MyGene.info

Gene · Ensembl

cytoskeleton associated protein 5

Symbol: CKAP5
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:46,742,768-46,846,308
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8844
exact match: identifiers.org/ncbigene/9793
genomic end: 46867847
genomic start: 46764598
cytogenetic location: 11p11.2

Sources (4)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Interactions
References
External links
Further reading

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.

It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.