MFAP5
Sign in to saveAlso known as MAGP-2, MAGP2, MFAP-5, MP25, AAT9, microfibrillar associated protein 5, microfibril associated protein 5
Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.
In the Vinony graph
Within Vinony's link graph, MFAP5 is referenced by 7 other articles, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 12.
Its subject is documented across 6 Wikipedia language editions.
Gene data
MFAP5- Name
- microfibril associated protein 5
- Type
- protein-coding
- Position
- 8,637,346–8,672,519 (−)
- Aliases
- AAT9, MAGP-2, MAGP2, MFAP-5, MP25
- Ensembl
- ENSG00000197614
- RefSeq RNA
- NM_001297709.2, NM_001297710.2, NM_001297711.2, NM_001297712.2, NM_003480.4
- RefSeq protein
- NP_001284638.1, NP_001284639.1, NP_001284640.1, NP_001284641.1, NP_003471.1
This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
microfibril associated protein 5
- Symbol
- MFAP5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:8,637,346-8,672,519
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2599
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8076
- chromosome
- human chromosome 12
- genomic start
- 8789942
- genomic end
- 8815484
- cytogenetic location
- 12p13.31
- expressed in
- decidua
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.
This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.
Excerpted from Wikipedia’s “MFAP5” article, available under the CC BY-SA 4.0 licence.