MFAP5

Also known as MAGP-2, MAGP2, MFAP-5, MP25, AAT9, microfibrillar associated protein 5, microfibril associated protein 5

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.

Gene data

MFAP5

Name: microfibril associated protein 5
Type: protein-coding
Position: 8,637,346–8,672,519 (−)
Aliases: AAT9, MAGP-2, MAGP2, MFAP-5, MP25
Ensembl: ENSG00000197614
RefSeq RNA: NM_001297709.2, NM_001297710.2, NM_001297711.2, NM_001297712.2, NM_003480.4
RefSeq protein: NP_001284638.1, NP_001284639.1, NP_001284640.1, NP_001284641.1, NP_003471.1

This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].

Gene Ontology

Biological process

embryonic eye morphogenesis definitive hemopoiesis definitive hemopoiesis

Molecular function

extracellular matrix structural constituent extracellular matrix structural constituent microfibril binding

Cellular component

microfibril microfibril microfibril extracellular region extracellular matrix extracellular matrix

Pathways

Extracellular matrix organization Extracellular matrix organization Elastic fibre formation Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres MFAP5-mediated ovarian cancer cell motility and invasiveness MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

via MyGene.info

Gene · Ensembl

microfibril associated protein 5

Symbol: MFAP5
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:8,637,346-8,672,519
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 2599
exact match: identifiers.org/ncbigene/8076
genomic start: 8789942
genomic end: 8815484
cytogenetic location: 12p13.31

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Further reading

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.

This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.