E2F5

Name

E2F transcription factor 5

Type

protein-coding

Position

85,177,154–85,217,158 (+)

Aliases

E2F-5

Ensembl

ENSG00000133740

RefSeq RNA

NM_001083588.2, NM_001083589.2, NM_001951.4

RefSeq protein

NP_001077057.1, NP_001077058.1, NP_001942.2

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

E2F transcription factor 5

Symbol

E2F5

Biotype

Protein coding

Organism

Homo sapiens

Location

8:85,177,107-85,217,158

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein E2F5 PDB 1cf7.png

via Wikidata · CC0