E4F1

Also known as E4F, E4F transcription factor 1

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.

Gene data

E4F1

Name: E4F transcription factor 1
Type: protein-coding
Position: 2,223,440–2,235,743 (+)
Aliases: E4F
Ensembl: ENSG00000167967
RefSeq RNA: NM_001288776.2, NM_001288778.2, NM_004424.5, XM_005255155.2, XM_005255156.2
RefSeq protein: NP_001275705.2, NP_001275707.2, NP_004415.4, XP_005255212.1, XP_005255213.1

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.

== Function == The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.