ICAM5
Sign in to saveAlso known as TLCN, TLN, intercellular adhesion molecule 5
Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.
In the Vinony graph
Within Vinony's link graph, ICAM5 is referenced by 72 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 19.
Its subject is documented across 5 Wikipedia language editions.
Gene data
ICAM5- Name
- intercellular adhesion molecule 5
- Type
- protein-coding
- Position
- 10,289,940–10,296,778 (+)
- Aliases
- TLCN, TLN
- Ensembl
- ENSG00000105376
- RefSeq RNA
- NM_003259.4, XM_054321900.1
- RefSeq protein
- NP_003250.3, XP_054177875.1
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
intercellular adhesion molecule 5
- Symbol
- ICAM5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:10,289,940-10,296,778
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 2447
- chromosome
- human chromosome 19
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7087
- genomic end
- 10407454
- genomic start
- 10289952
- cytogenetic location
- 19p13.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
Excerpted from Wikipedia’s “ICAM5” article, available under the CC BY-SA 4.0 licence.