TAC4

Also known as EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to TAC4, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 17.

Vinony links it to 5 Wikipedia language editions.

Gene data

TAC4

Name: tachykinin precursor 4
Type: protein-coding
Position: 49,838,300–49,848,071 (−)
Aliases: EK, HK-1, PPT-C
Ensembl: ENSG00000176358
RefSeq RNA: NM_001077503.2, NM_001077504.2, NM_001077505.2, NM_001077506.2, NM_170685.3
RefSeq protein: NP_001070971.1, NP_001070972.1, NP_001070973.1, NP_001070974.1, NP_733786.2

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of systemic arterial blood pressure inflammatory response positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway tachykinin receptor signaling pathway detection of temperature stimulus involved in sensory perception of pain regulation of sensory perception of pain

Molecular function

substance P receptor binding substance P receptor binding substance K receptor binding receptor ligand activity

Cellular component

extracellular region extracellular region extracellular region

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Peptide GPCRs

via MyGene.info

Gene · Ensembl

tachykinin precursor 4

Symbol: TAC4
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:49,838,300-49,848,071
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 89219
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/255061
genomic end: 49848069
genomic start: 49838300
chromosome: human chromosome 17
cytogenetic location: 17q21.33

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.

Excerpted from Wikipedia’s “TAC4” article, available under the CC BY-SA 4.0 licence.