COPS8
Sign in to saveAlso known as COP9, CSN8, SGN8, COP9 signalosome subunit 8
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.
In the Vinony graph
Within Vinony's link graph, COPS8 is referenced by 3 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Its subject is documented across 6 Wikipedia language editions.
Gene data
COPS8- Name
- COP9 signalosome subunit 8
- Type
- protein-coding
- Aliases
- COP9, CSN8, SGN8
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
COP9 signalosome subunit 8
- Symbol
- COPS8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:237,085,877-237,103,208
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 4882
- exact match
- identifiers.org/ncbigene/10920
- genomic end
- 237100474
- genomic start
- 237085882
- chromosome
- human chromosome 2
- cytogenetic location
- 2q37.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.
The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Excerpted from Wikipedia’s “COPS8” article, available under the CC BY-SA 4.0 licence.