COPS8

Also known as COP9, CSN8, SGN8, COP9 signalosome subunit 8

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.

Gene data

COPS8

Name: COP9 signalosome subunit 8
Type: protein-coding
Aliases: COP9, CSN8, SGN8

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

COP9 signalosome subunit 8

Symbol: COPS8
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:237,085,877-237,103,208
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 4882
exact match: identifiers.org/ncbigene/10920
genomic end: 237100474
genomic start: 237085882
cytogenetic location: 2q37.3

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COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.

The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.