CD69 molecule
Sign in to saveAlso known as leukocyte surface antigen Leu-23, MLR-3, C-type lectin domain family 2 member C, activation inducer molecule (AIM/CD69), CD69 antigen (p60, early T-cell activation antigen), early activation antigen CD69, GP32/28, early T-cell activation antigen p60
CD69 (Cluster of Differentiation 69) is a human transmembrane C-type lectin protein encoded by the gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. It is also implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs.
Protein · UniProt
Early activation antigen CD69
- Gene
- CD69
- Organism
- Homo sapiens (Human)
- Length
- 199 aa
- Molecular mass
- 22,559 Da
- Evidence
- 1: Evidence at protein level
Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 c…
Swiss-Prot (reviewed) · via UniProt
Research
1,474 papersvia PubMed
~5 min read
Article
8 sectionsContents
- Function
- Structure and ligands
- T cell differentiation
- Lymphocyte migration
- See also
- References
- Further reading
- External links
CD69 (Cluster of Differentiation 69) is a human transmembrane C-type lectin protein encoded by the gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. It is also implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs.
== Function ==