CD69 molecule
Sign in to saveAlso known as leukocyte surface antigen Leu-23, MLR-3, C-type lectin domain family 2 member C, activation inducer molecule (AIM/CD69), CD69 antigen (p60, early T-cell activation antigen), early activation antigen CD69, GP32/28, early T-cell activation antigen p60
CD69 (Cluster of Differentiation 69) is a human transmembrane C-type lectin protein encoded by the gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. It is also implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs.
In the Vinony graph
Within Vinony's link graph, CD69 molecule is referenced by 372 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It is catalogued under topics including Clusters of differentiation and Genes on human chromosome 12.
Its subject is documented across 9 Wikipedia language editions.
Protein · UniProt
Early activation antigen CD69
- Gene
- CD69
- Organism
- Homo sapiens (Human)
- Length
- 199 aa
- Molecular mass
- 22,559 Da
- Evidence
- 1: Evidence at protein level
Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 c…
Swiss-Prot (reviewed) · via UniProt
Research
1,474 papersvia PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- biological process
- signal transduction
- found in taxon
- Homo sapiens
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Function
- Structure and ligands
- T cell differentiation
- Lymphocyte migration
- See also
- References
- Further reading
- External links
CD69 (Cluster of Differentiation 69) is a human transmembrane C-type lectin protein encoded by the gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system. It is also implicated in T cell differentiation as well as lymphocyte retention in lymphoid organs.
== Function ==
Excerpted from Wikipedia’s “CD69 molecule” article, available under the CC BY-SA 4.0 licence.