CD63 molecule
Sign in to saveAlso known as ocular melanoma-associated antigen, melanoma-associated antigen MLA1, lysosome-associated membrane glycoprotein 3, CD63 antigen (melanoma 1 antigen), OMA81H, lysosomal-associated membrane protein 3, CD63, LAMP-3
CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.
Protein · UniProt
CD63 antigen
- Gene
- CD63
- Organism
- Homo sapiens (Human)
- Length
- 238 aa
- Molecular mass
- 25,637 Da
- Evidence
- 1: Evidence at protein level
Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the …
Swiss-Prot (reviewed) · via UniProt
Research
761 papers- CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles.Blood · 2021
- Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution.Journal of extracellular vesicles · 2021
- Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations.Autophagy · 2022
- Basophil Degranulation Assay.Methods in molecular biology (Clifton, N.J.) · 2017
- Single Extracellular VEsicle Nanoscopy.Journal of extracellular vesicles · 2023
via PubMed
~3 min read
Article
8 sectionsContents
- Function
- Allergy diagnosis
- Research
- Interactions
- See also
- References
- Further reading
- External links
CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.
== Function ==