DLG5

Also known as LP-DLG, P-DLG5, PDLG, discs large homolog 5, discs large MAGUK scaffold protein 5

Disks large homolog 5 is a protein that in humans is encoded by the DLG5 gene.

In the Vinony graph

Within Vinony's link graph, DLG5 is referenced by 5 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 6 Wikipedia language editions.

Gene data

DLG5

Name: discs large MAGUK scaffold protein 5
Type: protein-coding
Position: 77,790,778–77,927,220 (−)
Aliases: LP-DLG, P-DLG5, PDLG, YUVOB
Ensembl: ENSG00000151208
RefSeq RNA: NM_004747.4, XM_005270276.5, XM_006718056.4, XM_006718057.4, XM_011540341.4
RefSeq protein: NP_004738.3, XP_005270333.1, XP_006718119.1, XP_006718120.1, XP_011538643.1

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008].