DLG1

Also known as DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187

Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene.

Gene data

DLG1

Name: discs large MAGUK scaffold protein 1
Type: protein-coding
Position: 197,042,560–197,299,332 (−)
Aliases: DLGH1, SAP-97, SAP97, hdlg
Ensembl: ENSG00000075711
RefSeq RNA: NM_001098424.1, NM_001204386.1, NM_001204387.2, NM_001204388.2, NM_001290983.2
RefSeq protein: NP_001091894.1, NP_001191315.1, NP_001191316.1, NP_001191317.1, NP_001277912.1

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018].

Pathways

Hippo signaling pathway - Homo sapiens (human)Tight junction - Homo sapiens (human)T cell receptor signaling pathway - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission Transmission across Chemical Synapses Transmission across Chemical Synapses

via MyGene.info

Gene · Ensembl

discs large MAGUK scaffold protein 1

Symbol: DLG1
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:197,042,560-197,299,332
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein DLG1 PDB 1iu0.png

Show 5 more facts

HomoloGene ID: 20869
exact match: identifiers.org/ncbigene/1739
genomic end: 197299330
genomic start: 196769431
cytogenetic location: 3q29

Sources (4)

via Wikidata · CC0

~3 min read

Article

6 sections

Contents

Function
Clinical significance
Structure
References
Further reading
External links

Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene.

SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein Dlg1 (the protein is alternatively referred to as hDlg1, and the human gene is DLG1). SAP97 is expressed throughout the body in epithelial cells. In the brain it is involved in the trafficking of ionotropic receptors from the endoplasmic reticulum to the plasma membrane, and may be involved in the trafficking AMPAR during synaptic plasticity.